Decellularization of rat aortic valve allografts reduces leaflet destruction and extracellular matrix remodeling
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چکیده
منابع مشابه
Decellularization of rat aortic valve allografts reduces leaflet destruction and extracellular matrix remodeling.
OBJECTIVES Decellularization of aortic valve allografts in advance of transplantation is a promising approach to overcome immune-induced early graft failure. In this study the effects of in vitro cell extraction on extracellular matrix molecules and in vivo remodeling of decellularized aortic valves were investigated in a heterotopic aortic valve rat implantation model. METHODS Rat aortic val...
متن کاملDecellularization reduces the immune response to aortic valve allografts in the rat.
OBJECTIVES Cryopreserved valve allografts used in congenital cardiac surgery are associated with a significant cellular and humoral immune response. This might be reduced by removal of antigenic cellular elements (decellularization). The aim of this study was to determine the immunologic effect of decellularization in a rat allograft valve model. METHODS Brown Norway and Lewis rat aortic valv...
متن کاملDecellularization of Rat Aortic Valve Allografts Reduces the Cellular Immune Response Resulting in a Structurally Intact Collagen Network Irrespective of Collagen Denaturation
Background There is increasing evidence that the immunogenicity of aortic valve allografts (AVA) is associated with valvular degeneration. Chemically induced cell extraction is expected to reduce an immune response. However, whether this will translate into reduced structural damage is unclear. The present study focussed at characterizing the immune response to cellular and acellular AVA and co...
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Degenerative aortic stenosis (AS) is the most common worldwide cause of valve replacement. The aortic valve is a thin, complex, layered connective tissue with compartmentalized extracellular matrix (ECM) produced by specialized cell types, which directs blood flow in one direction through the heart. There is evidence suggesting remodeling of such ECM during aortic stenosis development. Thus, a ...
متن کاملAortic valve allografts in sheep.
Some of the mechanical and biological problems surrounding the use of fresh allograft inverted aortic valves as mitral valve substitutes are described. Certain aspects of the problem have been studied expzrimentally. In three sheep 'fresh' aortic valve allografts were-inserted, using cardio-pulmonary bypass, into the main pulmonary artery, and were observed from 5 to 7 months after operation. T...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2003
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(03)00956-5